Vitamin D, vitamin D binding protein, lung function and structure in COPD
نویسندگان
چکیده
منابع مشابه
Vitamin D, Vitamin D Binding Protein, and Longitudinal Outcomes in COPD
BACKGROUND Associations between Vitamin D3 [25(OH)D], vitamin D binding protein (VDBP) and chronic obstructive pulmonary disease (COPD) are previously reported. We aimed to further investigate these associations on longitudinal outcomes. METHODS 426 COPD patients from western Norway, GOLD stage II-IV, aged 40-76, were followed every six-month from 2006 through 2009 with spirometry, bioelectri...
متن کاملVitamin D and lung function.
Afzal et al recently reported that low plasma 25-hydroxyvitamin D is associated with a decline in lung function and chronic obstructive pulmonary disease (COPD). While this finding persisted after adjustment for possible confounding variables, and concurs with the findings of others, we believe it might still be spurious. First, we suggest the association between plasma vitamin D and lung funct...
متن کاملVitamin D Binding Protein and Vitamin D Levels
1 Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China 2 Clinical Research, Diabetes and Endocrinology, Merck Research Laboratories, 126 East Lincoln Avenue, RY34B-148, Rahway, NJ 07065-0900, USA 3Department of Nutritional Science, Rutgers University, New Brunswick, NJ 08901, USA 4Division of Endocrinology, Metabolism an...
متن کاملVitamin D-binding protein prevents vitamin D deficiency and presents vitamin D for its renal activation.
Two mouse models in which the vitamin D-binding protein (DBP) or megalin, a DBP receptor, were knocked out have recently confirmed that DBP is essential for normal vitamin D homeostasis, and have revealed a major pathway for vitamin D activation (1, 2). DBP is also known as the group-specific component of serum (Gc-globulin). It is a highly polymorphic 58 kDa glycoprotein, which has been used a...
متن کاملThe vitamin D axis in the lung: a key role for vitamin D-binding protein.
There has been much recent interest in the role of the vitamin D axis in lung disease, which includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also known as Gc-globulin). VDBP is a serum protein which has immunomodulatory functions relevant in the lung, predominantly relating to macrophage activation and neutrophil chemotaxis. Variations within its gene are also ...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 2013
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2013.05.010